Created by Jiří Kofránek
Alveolární ventilace-animace.pptx
HIF-1 is a complex of 2 subunits: a subunit (HIF-1α), the formation of which is regulated by oxygen levels, and a constitutively produced subunit (HIF-1β). Under aerobic conditions, HIF-1α is degraded in the ubiquitin protein ligase complex after hydroxylation by prolyl hydroxylase (PHD), i.e. it is almost not found in the cytoplasm of the cell. In hypoxia, hydroxylation does not occur, HIF-1α accumulates and combines with HIF-1β to form HIF-1. HIF-1 then affects the expression of a number of genes leading to the production of growth factors and other bioactive substances as part of adaptation to hypoxia. HIF – hypoxia-inducible factor, VEGF – vascular endothelial growth factor, EPO – erythropoietin, PDK1 – pyruvate dehydrogenase 1, PHD – prolyl hydroxylase, ARNT – aryl hydrocarbon receptor nuclear translocator, NF-κB – nuclear factor κ B
HIF-1 is a complex of 2 subunits: a subunit (HIF-1α), the formation of which is regulated by oxygen levels, and a constitutively produced subunit (HIF-1β). Under aerobic conditions, HIF-1α is degraded in the ubiquitin protein ligase complex after hydroxylation by prolyl hydroxylase (PHD), i.e. it is almost not found in the cytoplasm of the cell. In hypoxia, hydroxylation does not occur, HIF-1α accumulates and combines with HIF-1β to form HIF-1. HIF-1 then affects the expression of a number of genes leading to the production of growth factors and other bioactive substances as part of adaptation to hypoxia. HIF – hypoxia-inducible factor, VEGF – vascular endothelial growth factor, EPO – erythropoietin, PDK1 – pyruvate dehydrogenase 1, PHD – prolyl hydroxylase, ARNT – aryl hydrocarbon receptor nuclear translocator, NF-κB – nuclear factor κ B
